EVALUATION OF IMMUNE RESPONSE ABILITY OF CIMAvax-EGF® VACCINE ON ICR MOUSE

Authors

  • Nguyen Thi Ly
  • Nguyen Kim Bach
  • Be Thi Tham
  • Nguyen Thi Hong Dinh
  • Do Linh Trang

DOI:

https://doi.org/10.56086/jcvb.v3i3.111

Keywords:

CIMAvax-EGF®, ICR mouse, ELISA

Abstract

The study evaluated the immune response of CIMAvax-EGF® vaccine on Mlac: ICR mouse line has compared with the control serum samples on MNRI mouse by ELISA. The study results showed that with the designed immunogenic doses (0.1; 0.15; 0.2; 0.25 & 0.3 ml of CIMAvax-EGF® vaccine/mouse) after 14 days, using 03 serum dilutions include: 1/100, 1/1000 & 1/10000 for ELISA test gave similar results to the NMRI mouse serum standard sample provided by the manufacturer. The optimal immunogenic dose in Mlac: ICR mouse line is 0.2ml of CIMAvax-EGF® vaccine/mouse.

 From the above research results, it was possible to use Mlac: ICR mouse line of National Institute for Control of Vaccines and Biologicals (NICVB) at NICVB's laboratory for potency test of CIMAvax-EGF® vaccine produced by Cuban.

Published

21-09-2023

How to Cite

Nguyen Thi Ly, Nguyen Kim Bach, Be Thi Tham, Nguyen Thi Hong Dinh, & Do Linh Trang. (2023). EVALUATION OF IMMUNE RESPONSE ABILITY OF CIMAvax-EGF® VACCINE ON ICR MOUSE. JOURNAL OF CONTROL VACCINES AND BIOLOGICALS, 3(3), 80–87. https://doi.org/10.56086/jcvb.v3i3.111

Issue

Vol. 3 No. 3 (2023)

Section

Articles

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