DETERMINATION OF SOME BLOOD PHYSIOLOGICAL PARAMETERS OF ICR MICE ARE CARED IN NATIONAL INSTITUTE FOR CONTROL OF VACCINES AND BIOLOGICALS

Abstract

ICR mice widely used in biomedical studies and verificative test, was first transferred to Vietnam to be cared for and bred in National Institute for Control of Vaccines and Biologicals (NICVB). Before being used for the testing, animals should be checked for complete blood count to assess the animal's health status and to ensure reliability regarding the results of the experiment. Evaluation of the quality of vaccines and biologicals strictly requires the quality of experimental animals. Similarly, in order to quality experimental animals, the breeding herd before being put into breeding also needs to be checked and evaluated for their health. The study was carried out on 80 ICR mice (40 male and 40 female), 20 mice per age-group (3 – 4 and 8 – 10 weeks of age) with the target of initially building reference parameters for the blood physiological index of ICR mice cared in Vietnamese conditions. The results of the study are presented in the form of table, showed the mean, standard deviation, minimum and maximum values of blood physiological parameters of ICR mice at 3 – 4 and 8 – 10 weeks of age between male and female include: erythrocyte parameters ( RBC, HCT, MCV, HGB, MCHC và MCH), leukocyte parameters (WBC, Lym, Neu, Mon, Eos và Bas) và platelet count (PLT). The study showed that the blood physiological parameters of ICR mice cared in National Institute for Control of Vaccines and Biologicals were similar to the research results from Charles River.