CHARACTERISTICS AND VALUE OF ANTENATAL ULTRASOUND SCREENING FOR CHROMOSOMAL ABNORMALITIES IN PREGNANT WOMENT WITH AMNIOCENTESIS IN NGHE AN PROVINCE (2020 – 2021)

Abstract

Ultrasonography is of great value in screening for fetal chromosomal abnormalities and helping to precisely indicate amniocentesis. Objective was to find out morphological abnormalities and value of ultrasound in prenatal screening test at Nghe An Obstetrics and Gynecology Hospital (2020-2021). By methods of ultrasound, Double test, Tripple test and chromosomal test for 121 pregnant women who were indicated for amniocentesis. The study results showed the mean age of the pregnant women was 32 ± 6.69 years, the group ≥ 35 years old accounted for 40.5%. Ultrasound abnormalities accounted for the highest component of women with amniocentesis (62.8%), followed by age of 35 years or over (40.5%), high-risk prenatal screening tests ( 35.5%). The rate of fetuses with abnormal ultrasound image was 62.8%. The most common ultrasound abnormalities were increased nuchal translucency (12.6%), nasal bone aplasia (5.5%). The rate of fetal chromosomal abnormalities was 15.7%. There were 22.3% of fetuses with ultrasound abnormalities having chromosomal abnormalities. The sensitivity, specificity, false-negative and false-positive rates of ultrasound in predicting chromosomal abnormality were 89.5%; 42.2%; 10.5% and 57.8% respectively. Conclusion was ultrasound can detect many morphological abnormalities and has high sensitivity in predicting fetal chromosomal abnormalities.